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. 2022 Nov 2;12:943064. doi: 10.3389/fonc.2022.943064

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Copyright © 2022 Mancini, Colapietro, Cristiano, Rossetti, Mattei, Gravina, Perez-Montoyo, Yeste-Velasco, Alfon, Domenech and Festuccia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ABTL0182 inhibits tumor growth in an orthotopic model of glioblastoma in mice that reproduces the clinical setting after surgical removal of tumors. (A) Diagram showing the experimental design of the treatment of glioblastoma orthotopic models using U87MG and GSCs-5 luciferase-tagged cells ortotopically inoculated into the brain of athymic nude mice and treated with ABTL0812 (120 and 240 mg/Kg) and Everolimus (5 mg/Kg). Tumors were monitored by bioluminescence detection which was performed every 7 days in order to determine Disease Free Survival (DFS) and Overall Survival (OS). (B) DFS of mice bearing orthotopic tumor of U87MG-Luc cells. (C) Overall survival of mice bearing U87MG-Luc cells orthotopic tumors. (D) DFS of mice bearing orthotopic tumor of GSC-5 -Luc cells. (E) Overall survival of mice bearing GSC-5 -Luc cells orthotopic tumors. Statistical significance levels: *p<0.05, **p<0.01, ***p<0.01 n=10 in each group. CTRL= control vehicle-treated cells.