Table A1.
SCS Clinical Trials on ClinicalTrials.gov April 28, 2022
| Study Name | Type of Stimulation | Information Provided by (Location) | Status | Estimated/Actual Participants (n) | Primary Outcomes | NCT |
|---|---|---|---|---|---|---|
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following SCI (STIMO HEMO) | ESCS | Bloch, Jocelyne (Center Hospitalier Universitaire Vaudois) | R | 8 | BP during OH tilt table test | NCT04994886 |
| Non-Invasive Spinal Cord Stimulation After Injury | TSCS | Ovechkin, Alex (University of Louisville) | R | 36 | V̇o2 | NCT03998527 |
| Transformation of Paralysis to Stepping | TSCS | Ovechkin, Alex (University of Louisville) | R | 15 | Body temp, BP, HR, respiration rate, DEXA scan | NCT04105114 |
| Epidural Stimulation After Neurologic Damage (E-STAND) | ESCS | University of Minnesota | R | 100 | BP, cerebral blood flow during tilt table test | NCT03026816 |
| Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation | ESCS | Harkema, Susan (University of Louisville) | A, NR | 16 | RMR after 1 y of treatment | NCT04123847 |
| Recovery of Cardiovascular Function With Epidural Stimulation After Human SCI | ESCS | Harkema, Susan (University of Louisville) | C | 4 | CV function | NCT02037620 |
| Task-specific Epidural Stimulation Study (TS EPI) | ESCS | Harkema, Susan (University of Louisville) | R | 36 | CV function | NCT03364660 |
| SCI Epidural Stimulation | ESCS | Zhao, Kristin (Mayo Clinic) | C | 2 | Thermoregulation, body fat, bone density, lean mass | NCT02592668 |
| Epidural Stimulation After SCI (ESL-SCI) | ESCS | McGuire Research Institute | NYR | 5 | O2 consumption and BP (sitting, standing, walking), body composition (before and after training) | NCT04105296 |
| Neuromodulation Techniques After SCI | EKSO suit + ESCSEKSO suit + TSCS | Virginia Office of Research Development | R | 10 | Fat mass and fat free mass (every 3 months), O2 consumption (sitting, standing, walking), fasting lipid profile | NCT04241250 |
| Effects of Transcutaneous Spinal Cord Stimulation in SCI* | TSCS | Korupolu, Radha (The University of Texas Health Science Center) | C | 15 | BP, HR | NCT03249454 |
| Spinal Cord Stimulation and Autonomic Response in People With SCI | TSCS | Phillips, Aaron (University of Calgary) | NYR | 46 | BP (continuous and episodic), cerebral blood flow, HR, sympathetic skin responses, tilt table OH challenge, cerebrovascular structural changes, catecholamine levels, AD QOL questionnaire | NCT03924388 |
| Neuromodulation to Improve Respiratory Function in Cervical SCI | ESCS | Lu, Daniel (UCLA) | R | 15 | BP (beginning and end of each stimulation session for safety) | NCT04883463 |
| Spinal Cord Stimulation to Augment Activity Based Therapy | TSCS | Shepherd Center (Atlanta, GA) | C | 18 | HR during training, RPE | NCT03240601 |
| Neuromodulation: Bladder Bowel and Sexual Function in SCI | TSCS | Krassioukov, Andrei (University of British Columbia) | NYR | 40 | BP (continuous for identifying AD events) | NCT04604951 |
| Improving Bowel Function and Quality of Life After SCI | ESCS | Herrity, April (University of Louisville) | R | 36 | Ambulatory BP and HR | NCT03949660 |
| Recovery of Bladder and Sexual Function After Human SCI | ESCS | Hubscher, Charles (University of Louisville) | R | 70 | Continuous BP monitoring | NCT04193709 |
| Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes | TSCS | Solinsky, Ryan (Spaulding Rehabilitation Hospital) | NYR | 10 | Muscle sympathetic nerve activity, HR, BP, galvanic skin response, AD and OH questionnaires | NCT04858178 |
A, active; BP, blood pressure; C, completed; CV, cardiovascular; DBP, diastolic blood pressure; ESCS, epidural spinal cord stimulation; NR, not recruiting; NYR, not yet recruiting; OH, orthostatic hypotension; R, recruiting; SBP, systolic blood pressure; SCI, spinal cord injury; TSCS, transcutaneous spinal cord stimulation.