Fig 4. Reconstructing the timeline of CLL evolution in patients.

We applied our methodology to estimate subclonal growth rates, mutation rates and evolutionary timelines in CLL tumors from Ref. [27]. Vertical height of a clone represents its log₁₀-scaled size. Mutations were clustered into clones and phylogenetic trees were inferred using PhylogicNDT [43]. Tree edges are colored by clone number and are labeled with driver mutations, if any. For each patient, we show estimates for patient age at CLL initiation and times of appearance of CLL subclones. Dashed white line indicates when the patient was diagnosed. Solid black arrows indicate times of bulk sequencing measurements.