Table 2. Confidence intervals for inferred parameters for CLL patients with exponential growth patterns, for which there are at least two longitudinal bulk sequencing measurements before treatment.
Estimates are computed from tumor size measurements and mutation frequencies from whole exome sequencing. Mutation rates are for the exome only. The time estimates are in terms of the patient’s age in years.
| Parameter | Pt. 3 | Pt. 6 | Pt. 9 | Pt. 21 |
|---|---|---|---|---|
| r (/yr) | [0.20, 0.85] | [0.15, 1.30] | [0.17, 0.42] | [0.30, 1.14] |
| r1 (/yr) | [0.65, 1.04] | [0.08, 0.73] | [-0.45, -0.19] | [1.01, 2.04] |
| r2 (/yr) | [0.08, 0.85] | [0.49, 0.94] | ||
| r3 (/yr) | [0.65, 1.78] | [0.39, 0.86] | ||
| u (mut/yr) | [0.39, 0.59] | [0.12, 0.19] | [0.35, 0.37] | [0.19, 0.23] |
| MRCA (yr) | [1.4, 26.8] | [0.1, 13.2] | [1.2, 10.8] | [0.3, 16.7] |
| t1 (yr) | [24.1, 39.2] | [21.7, 46.1] | [8.8, 35.1] | [10.8, 24.0] |
| t2 (yr) | [25.6, 57.5] | [7.7, 31.7] | ||
| t3 (yr) | [31.3, 54.6] | [10.3, 37.6] | ||
| age at leukocytosis (yr) | [60.3, 62.4] | [64.2, 67.1] | [51.6,51.9] | [32.8,34.6] |