Table 2.
Summary Sensitivities, Specificities, Diagnostic Odds Ratio, Positive Likelihood Ratio, Negative Likelihood Ratio and AUC of FIB-4 Index and NFS at Various Diagnostic Thresholds for the Prediction of Advanced Fibrosis and Significant Fibrosis
| Variable | Cutoff | No. of samples (No. of patients) |
Summary statistics (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | DOR | LR+ | LR– | AUC | |||
| Advanced fibrosis | ||||||||
| FIB-4 | All | 32 (13,764) | 0.42 (0.33–0.51) | 0.93 (0.91–0.95) | 10.83 (7.55–15.54) | 6.65 (5.01–8.83) | 0.61 (0.52–0.71) | 0.76 (0.74–0.81) |
| 1.02 to 1.45 | 20 (10,304) | 0.69 (0.59–0.77) | 0.64 (0.57–0.71) | 4.11 (2.24–7.55) | 1.96 (1.49–2.57) | 0.47 (0.33–0.67) | 0.73 (0.67–0.80) | |
| 1.515 to 2.09 | 5 (2,408) | 0.74 (0.58–0.85) | 0.80 (0.72–0.86) | 11.97 (7.48–19.16) | 3.82 (3.00–4.88) | 0.32 (0.20–0.51) | 0.82 (0.78–0.87) | |
| 2.67 | 18 (8,731) | 0.34 (0.27–0.42) | 0.95 (0.92–0.96) | 9.32 (6.26–13.87) | 6.46 (4.66–8.95) | 0.69 (0.62–0.77) | 0.74 (0.70–0.76) | |
| 3.25 | 9 (2,721) | 0.39 (0.22–0.59) | 0.95 (0.93–0.97) | 14.23 (5.92–34.19) | 8.97 (4.87–16.50) | 0.63 (0.45–0.86) | 0.76 (0.77–0.88) | |
| NFS | All | 33 (13,337) | 0.38 (0.28–0.50) | 0.94 (0.90–0.96) | 10.16 (7.18–14.37) | 6.60 (4.85–8.97) | 0.64 (0.54–0.76) | 0.74 (0.71–0.79) |
| –1.98 to –1.036 | 23 (10,158) | 0.70 (0.57–0.80) | 0.61 (0.53–0.69) | 3.77 (2.16–6.56) | 1.83 (1.46–2.28) | 0.48 (0.33–0.70) | 0.72 (0.66–0.79) | |
| –0.126 to 0.19 | 2 (1,962) | 0.61 (0.28–0.86) | 0.87 (0.79–0.92) | 10.79 (3.65–31.84) | 4.79 (3.13–7.35) | 0.44 (0.20–0.97) | 0.80 (0.78–0.88) | |
| 4.39 to 4.8 | 31 (11,471) | 0.31 (0.23–0.41) | 0.95 (0.93–0.97) | 10.17 (7.06–14.63) | 7.29 (5.34–9.93) | 0.71 (0.63–0.81) | 0.73 (0.71–0.81) | |
| Significant fibrosis | ||||||||
| FIB-4 | All | 6 (547) | 0.42 (0.16–0.73) | 0.93 (0.56–0.99) | 9.71 (2.43–38.70) | 6.05 (1.25–29.29) | 0.62 (0.40–0.95) | 0.68 (0.65–0.76) |
| 0.66 to 0.89 | 4 (434) | 0.69 (0.55–0.80) | 0.61 (0.44–0.76) | 3.58 (1.96–6.53) | 1.79 (1.26–2.55) | 0.50 (0.35–0.70) | 0.66 (0.61–0.77) | |
| 1.4 to 1.9 | 2 (136) | 0.65 (0.53–0.75) | 0.66 (0.51–0.79) | 3.69 (1.61–8.49) | 1.94 (1.21–3.09) | 0.52 (0.35–0.78) | 0.74 (0.54–0.85) | |
| 2.67 to 3.25 | 2 (151) | 0.06 (0.02–0.22) | 0.98 (0.94–1.00) | 4.25 (0.57–31.68) | 10.82 (0.47–257.67) | 0.93 (0.85–1.02) | 0.67 (0.61–0.73) | |
| NFS | All | 5 (539) | 0.25 (0.02–0.82) | 0.76 (0.37–0.94) | 1.16 (0.37–3.57) | 1.12 (0.50–2.49) | 0.96 (0.69–1.33) | 0.60 (0.52–0.69) |
| –3.168 to –1.455 | 2 (335) | 0.57 (0.28–0.81) | 0.68 (0.37–0.88) | 2.82 (1.53–5.18) | 1.78 (1.11–2.84) | 0.63 (0.42–0.94) | 0.61 (0.58–0.72) | |
| 0.676 | 3 (279) | 0.04 (0.01–0.25) | 0.92 (0.77–0.98) | 0.52 (0.07–3.59) | 0.54 (0.08–3.49) | 1.03 (0.96–1.12) | 0.53 (0.42–0.73) | |
| 1.292 | 2 (154) | 0.81 (0.59–0.92) | 0.27 (0.16–0.44) | 1.65 (0.50–5.36) | 1.12 (0.87–1.44) | 0.67 (0.26–1.73) | 0.67 (0.57–0.75) | |
AUC, area under curve; FIB-4, fibrosis-4; NFS, nonalcoholic fatty liver disease (NAFLD) fibrosis score; CI, confidence interval; DOR, diagnostic odds ratio; LR+, positive likelihood ratio; LR–, negative likelihood ratio.