Table 3.
Summary Sensitivities, Specificities, Diagnostic Odds Ratio, Positive Likelihood Ratio, Negative Likelihood Ratio and AUC of FIB-4 Index and NFS According to Region or Body Mass Index for Prediction of Advanced Fibrosis
| Variable | Cutoff | No. of samples (No. of patients) |
Summary statistics (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | DOR | LR+ | LR– | AUC | |||
| Region | ||||||||
| FIB-4 (F3) | Asia | 12 (3,388) | 0.48 (0.36–0.60) | 0.86 (0.80–0.91) | 6.09 (4.44–8.36) | 3.63 (2.77–4.75) | 0.59 (0.49–0.72) | 0.74 (0.71–0.77) |
| Europe | 6 (1,978) | 0.61 (0.43–0.76) | 0.91 (0.83–0.95) | 16.37 (7.93–33.74) | 6.95 (3.91–12.32) | 0.42 (0.27–0.64) | 0.80 (0.78–0.82) | |
| America | 8 (4,155) | 0.51 (0.37–0.65) | 0.85 (0.71–0.93) | 6.23 (2.51–15.47) | 3.52 (1.72–7.22) | 0.56 (0.42–0.75) | 0.73 (0.68–0.78) | |
| NFS (F3) | Asia | 12 (3,407) | 0.38 (0.24–0.54) | 0.90 (0.83–0.95) | 6.22 (4.52–8.57) | 4.20 (3.07–5.76) | 0.67 (0.55–0.82) | 0.70 (0.65–0.74) |
| Europe | 7 (2,098) | 0.55 (0.39–0.71) | 0.94 (0.85–0.98) | 21.94 (10.03–47.94) | 10.23 (4.43–23.64) | 0.46 (0.33–0.65) | 0.83 (0.80–0.86) | |
| America | 8 (4,447) | 0.50 (0.33–0.68) | 0.78 (0.64–0.87) | 3.70 (1.77–7.74) | 2.33 (1.44–3.77) | 0.62 (0.45–0.88) | 0.72 (0.69–0.76) | |
| Body mass index | ||||||||
| FIB-4 (F3) | <30 kg/m2 | 12 (3,870) | 0.50 (0.38–0.61) | 0.88 (0.82–0.92) | 7.67 (5.46–10.78) | 4.33 (3.21–5.85) | 0.56 (0.46–0.68) | 0.75 (0.71–0.82) |
| 30 to <35 kg/m2 | 10 (1,331) | 0.51 (0.38–0.64) | 0.88 (0.78–0.93) | 7.92 (3.73–16.81) | 4.33 (2.39–7.85) | 0.54 (0.41–0.71) | 0.74 (0.72–0.76) | |
| ≥35 kg/m2 | 4 (675) | 0.60 (0.48–0.71) | 0.82 (0.69–0.90) | 7.31 (5.29–10.12) | 3.49 (2.26–5.40) | 0.47 (0.39–0.57) | 0.77 (0.74–0.80) | |
| NFS (F3) | <30 kg/m2 | 12 (3,889) | 0.35 (0.23–0.50) | 0.93 (0.88–0.96) | 8.17 (5.54–12.05) | 5.60 (3.82–8.21) | 0.68 (0.57–0.82) | 0.71 (0.67–0.75) |
| 30 to <35 kg/m2 | 9 (4,583) | 0.51 (0.35–0.66) | 0.84 (0.75–0.91) | 5.96 (2.77–12.85) | 3.41 (1.98–5.86) | 0.57 (0.41–0.78) | 0.73 (0.70–0.67) | |
| ≥35 kg/m2 | 6 (2,205) | 0.55 (0.33–0.76) | 0.83 (0.61–0.94) | 6.37 (3.82–10.63) | 3.38 (1.81–6.32) | 0.53 (0.37–0.75) | 0.80 (0.74–0.85) | |
AUC, area under curve; FIB-4, fibrosis-4; NFS, nonalcoholic fatty liver disease (NAFLD) fibrosis score; CI, confidence interval; DOR, diagnostic odds ratio; LR+, positive likelihood ratio; LR–, negative likelihood ratio.