| 4.1 Smoking cessation |
7 |
3126 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.66 [1.52, 4.65] |
| 4.2 Adverse events |
4 |
765 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.22 [1.12, 1.32] |
| 4.2.1 12 weeks |
2 |
657 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.20 [1.11, 1.30] |
| 4.2.2 16 weeks |
1 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.18 [0.67, 2.07] |
| 4.2.3 6 months |
1 |
58 |
Risk Ratio (M‐H, Fixed, 95% CI) |
11.00 [0.64, 190.26] |
| 4.3 Serious adverse events |
9 |
1993 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.54, 1.97] |
| 4.3.1 4 to 6 weeks |
2 |
246 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 4.3.2 8 weeks |
1 |
240 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.29 [0.06, 1.35] |
| 4.3.3 12 weeks |
2 |
858 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.69 [0.21, 66.17] |
| 4.3.4 16 weeks |
1 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 4.3.5 6 months |
2 |
307 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.71 [0.16, 3.10] |
| 4.3.6 8 months |
1 |
292 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.78 [0.68, 4.70] |
| 4.4 Carbon monoxide (ppm) |
11 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.4.1 Change from baseline |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.4.2 Absolute values at follow‐up |
9 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.5 Heart rate (bpm) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.5.1 Absolute values at follow‐up |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.6 Systolic blood pressure |
3 |
298 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.30 [‐3.91, ‐0.69] |
| 4.6.1 Change from baseline |
1 |
168 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.68 [‐4.38, ‐0.98] |
| 4.6.2 Absolute values at follow‐up |
2 |
130 |
Mean Difference (IV, Fixed, 95% CI) |
1.11 [‐3.95, 6.18] |
| 4.7 Blood oxygen saturation |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.7.1 Absolute values at follow‐up |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.8 3‐HPMA (SMD) |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.8.1 Absolute values at follow‐up |
1 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.8.2 Change from baseline |
1 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.9 NNAL (SMD) |
5 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.9.1 Absolute values at follow‐up |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.9.2 Change from baseline |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.10 2‐HPMA (pmol/mg creatinine) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.10.1 Absolute values at follow‐up |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.11 HMPMA (pmol/mg creatinine) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.11.1 Absolute values at follow‐up |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.12 PheT (pmol/mg creatinine) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.12.1 Absolute values at follow‐up |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.13 CEMA (pmol/mg creatinine) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.13.1 Absolute values at follow‐up |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.14 AAMA (pmol/mg creatinine) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.14.1 Absolute values at follow‐up |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.15 S‐PMA (nanograms) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.15.1 12 weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.16 FEV1 (SMD) |
2 |
714 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.15 [‐0.01, 0.31] |
| 4.16.1 Change from baseline |
2 |
714 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.15 [‐0.01, 0.31] |
| 4.17 FEF 25‐75 (litres/second)) |
2 |
555 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.06 [‐0.18, 0.06] |
| 4.17.1 Change from baseline |
2 |
555 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.06 [‐0.18, 0.06] |
| 4.18 PEF 25‐75 (litres/minute) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.18.1 Change from baseline |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.19 FEV1/FVC |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 4.19.1 Change from baseline |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
