Comparison 14. Nicotine EC + NRT versus NRT.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
14.1 Smoking cessation	2	980	Risk Ratio (M‐H, Fixed, 95% CI)	3.53 [1.93, 6.44]
14.2 Adverse events	3	1984	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.83, 1.11]
14.2.1 12 weeks	2	421	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.69, 1.11]
14.2.2 7 months	1	1563	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.82, 1.19]
14.3 Serious adverse events	4	2245	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.46, 3.42]
14.3.1 5 weeks	1	7	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
14.3.2 12 weeks	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	3.00 [0.13, 70.30]
14.3.3 6 months	1	625	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.39, 3.27]
14.3.4 7 months	1	1563	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable