NCT02398487.

Study name	Head‐to‐head comparison of personal vaporizers versus cig‐a‐like: prospective 6‐month randomized control design study (VAPECIG 2)
Methods	Randomized parallel‐assignment open‐label trial Setting: Italy, community
Participants	Estimated enrolment: 200 Inclusion criteria: (People who smoke) in good general health Committed to follow trial procedures Exclude if: Recent vaping history (stopped vaping < 3 months ago) Use of any other form of non‐combustible nicotine‐containing products (chewable tobacco or nicotine replacement therapy) Symptomatic cardiovascular disease Clinical history of asthma and COPD Regular psychotropic medication use Current or past history of alcohol abuse Use of smokeless tobacco or nicotine replacement therapy Pregnancy or breastfeeding
Interventions	Comparison between 2 types of EC; 'personal vaporizers' and 'cig‐a‐like'
Outcomes	24 weeks: Smoking cessation Smoking reduction
Starting date	October 2014
Contact information	Riccardo Polosa
Notes