| Participants |
Estimated enrolment: 260
Inclusion criteria:
Adult (> 18 yrs) Regular smoking (> 10 cigarettes a day; for at least 1 year) Exhaled breath CO (eCO) level > 7 ppm Not currently attempting to quit smoking or wishing to do so in the next 30 days; this will be verified at screening by the answer ''NO'' to the question ''Do you intend to quit in the next 30 days?'' Schizophrenia spectrum disorder diagnosis (schizophrenia, delusional disorder, schizoaffective disorder, personality disorder, schizoid personality disorder, etc) by DSM‐V criteria Understand and provide informed consent Able to comply with all study procedures
Exclusion criteria:
Institutionalized patients Acute decompensation of schizophrenia spectrum disorder symptoms within the past month Change in antipsychotic treatment within the past month No recent history of hospitalization for any serious medical condition within 3 months prior to screening, as determined by the investigator Myocardial infarction or angina pectoris within 3 months prior to screening, as determined by the investigator Current poorly‐controlled asthma or COPD Pregnancy, planned pregnancy or breastfeeding. Any female participant who becomes pregnant during this study will be withdrawn. People who have a significant history of alcoholism or drug/chemical abuse within 12 months prior to screening, as determined by the investigator Accepting to take part in a smoking cessation programme People who regularly use any recreational nicotine (e.g. e‐cigarettes,) or tobacco product (e.g. tobacco heated products, oral smokeless) other than their own cigarettes within 30 days of screening People who have used smoking cessation therapies (e.g. varenicline, bupropion, or NRT) within 30 days of screening People who are still participating in another clinical study (e.g. attending follow‐up visits) or who have recently participated in a clinical study involving administration of an investigational drug (new chemical entity) within the past 3 months People who have, or who have a history of, any clinically‐significant neurological, gastrointestinal, renal, hepatic, cardiovascular, psychiatric, respiratory, metabolic, endocrine, haematological or other major disorder that, in the opinion of the investigator or their appropriately qualified designee, would jeopardize the safety of the participant or impact on the validity of the study results
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