Fig. 2.

Results of the pairwise MEMs fitting. In both the normal samples (T0) and three patient stages (T1, T2 and T3), the pairwise MEM showed good fitting performance and could predict appearance probability (Prob.) of brain activity patterns observed in empirical data (a). Based on the accurate fitting of pairwise MEMs, we estimated the energy values of all the $2^9$ brain states and built the energy landscape for each group. Their energy landscapes exhibited different hierarchal structures (b). We then identified the dominant brain activity patterns and summarized two complementary major activity patterns in normal samples and three patient stages (local minima A and B). (c) The baseline brain activity $h_i$ of isolated ROI and pairwise functional interations among the nine ROIs $J_{\mathit{ij}}$ were calculated (d).