Table 2.

Significant clusters of hypometabolism compared to healthy subjects based on voxel-to-voxel group comparisons for the left IA, left > IA, right IA and right > IA groups (p < 0.001, corrected for cluster volume).

	Cluster Volume (mm3)	x	y	z	T-voxel max
Left IA
Temporal superior, medium and inferior, hippocampus, para-hippocampus, amygdalae, fusiform, temporal pole superior and medium	3,485	−50	6	−34	6.5
Temporal superior and medium, occipital medium, supra-marginal, parietal superior	1,708	−42	−82	−6	4.8
Occipital superior, medium and inferior, cuneus, precuneus, lingual, calcarine	4,985	−14	−96	0	6.6
Contralateral occipital superior, medium and inferior, cuneus, lingual, calcarine
Fronto-orbital superior	113	−12	36	–32	7.1
Fronto-orbital mesial, medium and inferior	366	−26	42	−4	4.4
Parietal superior, occipital superior	86	−18	−84	−52	4.8
Insula, rolandic, inferior-opercular	137	−40	12	14	4.1
Contralateral temporal medium and inferior	294	60	−16	−18	4.8
Contralateral temporal medium and inferior	88	56	−44	−8	4.2
Contralateral temporal superior	211	60	–22	2	5.0
Contralateral fronto-orbital medium and inferior	720	44	36	−6	6.7
Contralateral parietal superior	99	42	−60	64	4.0
Contralateral pre and post central, rolandic, supramarginal	479	52	−20	28	5.2
Left > IA
Temporal superior, medium and inferior, hippocampus, para-hippocampus, fusiform, temporal pole superior and medium	4,786	−54	−2	−14	6.5
Occipital superior, medium and inferior, cuneus, precuneus, lingual, calcarine	2,142	−14	−92	−4	5.9
Contralateral occipital superior and inferior, cuneus, calcarine
Occipital medium	105	−42	−92	−4	4.2
Occipital medium and inferior	109	−42	−76	4	3.7
Fronto-orbital superior	178	−10	34	–32	6.8
Fronto-orbital medium and inferior	441	−28	40	−2	4.1
Pre and post central	133	−56	−14	18	4.0
Contralateral temporal superior, medium and inferior, temporal pole medium	1,699	50	−10	−26	5.9
Contralateral temporal medium and inferior	75	72	−18	−24	3.9
Contralateral fronto-orbital superior, medium and inferior, insula	774	44	34	−6	5.7
Contralateral supra marginal, post central, rolandic	439	52	−18	24	4.3
Contralateral cerebellum	131	26	−66	−40	3.5
Right IA
Temporal superior, medium and inferior, temporal pole superior and medium, occipital superior, medium and inferior, lingual, fusiform, calcarine, hippocampus, parahippocampus, amygdalae, cuneus, precuneus, parietal superior and inferior, angular, supra-marginal, pre and post central, rolandic, insula, fronto-orbital inferior, thalamus, putamen and pallidum	29,020	62	−16	−20	9.6
Contralateral occipital superior, medium and inferior, calcarine, lingual and cuneus
Frontal superior	142	20	60	6	4.5
Frontal inferior	81	48	26	26	3.5
Cerebellum	111	26	−62	−40	4.2
Cerebellum	233	40	−60	−62	5.2
Contralateral fronto-orbital medium, fronto-mesial superior	172	−10	58	−2	3.9
Right > IA
Temporal superior, medium and inferior, temporal pole superior and medium, occipital medium, lingual, fusiform, hippocampus, parahippocampus, parietal superior and inferior, angular, supra-marginal, post central, rolandic, insula, fronto-orbital medium and inferior, putamen and pallidum	12,558	60	−24	0	8.0
Contralateral fronto-orbital medium and frontal superior mesial	219	−10	56	−4	4.6
Occipital superior, medium and inferior, calcarine, cuneus	3,471	−12	−98	−4	6.7
Contralateral occipital superior, medium and inferior, calcarine, cuneus, lingual
Frontal superior and medium	281	24	50	16	3.7
Contralateral occipital medium and angular	126	−40	−72	32	3.7