Table 3.
Group differences in domain-specific clinical outcome z-scores.
| Domain | N (MS EDSS ≤ 1) | N (MS EDSS ≥ 2) | Mean ± SD (MS EDSS ≤ 1) | Mean ± SD (MS EDSS ≥ 2) | pFDR | T |
|---|---|---|---|---|---|---|
| Vision | 29/36 | 35/39 | −0.38 ± 0.46 | 0.31 ± 0.86 | < 0.001* | −3.987 |
| Motor | 36/36 | 38/39 | −0.39 ± 0.51 | 0.40 ± 0.94 | < 0.001* | −4.534 |
| Fatigue (FSS) | 33/36 | 36/39 | −0.63 ± 0.68 | 0.58 ± 0.87 | < 0.001* | −6.347 |
| Depression (BDI-II) | 29/36 | 33/39 | −0.37 ± 0.75 | 0.32 ± 1.06 | 0.004* | −2.918 |
| Cognition | 34/36 | 33/39 | −0.19 ± 0.66 | 0.17 ± 0.72 | 0.023* | −2.097 |
| Total brain atrophy | 33/36 | 32/39 | −0.28 ± 0.96 | 0.28 ± 0.94 | 0.014* | −2.345 |
| Lesion load | 35/36 | 39/39 | −0.36 ± 0.43 | 0.32 ± 1.22 | < 0.001* | −3.232 |
Table includes domain name, number of patients per group with complete data, group mean and standard deviation of computed Z-score, FDR-corrected p-value, and test statistic (T). MS EDSS ≤ 1: MS patients with expanded disability status scale score less than or equal to 1; MS EDSS ≥ 2: MS patients with expanded disability status scale score greater than or equal to 2; FDR: false discovery rate; FSS: Fatigue severity scale; BDI-II: Beck’s depression inventory – second edition.