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. 2022 Nov 2;611(7936):614–622. doi: 10.1038/s41586-022-05386-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, Sequencing read counts of wild-type (WT) and p35S::H2B.8-eGFP seedling Hi-C libraries. Rep, biological replicate. b, Correlations between the Hi-C data generated in this study and previously published^36,37. R, Pearson’s correlation coefficient. c, Hi-C interaction frequency heatmaps at 500 kb resolution for WT (upper; merged replicates) and p35S::H2B.8-eGFP (lower; merged replicates) seedlings. d, Genome-wide interaction frequency fold change heatmap between WT (Rep 2) and p35S::H2B.8-eGFP (Rep 2) seedlings at 500 kb resolution, as shown in Fig. 6a for Rep 1. e, Short-range intrachromosomal interaction frequency difference between p35S::H2B.8-eGFP (Rep 2) and WT (Rep 2) over quantiles of seedling H2B.8 enrichment (log₂(IP/input)), as shown in Fig. 6b for Rep 1. Spearman’s ρ = 0.930. f, Long-range interaction frequency difference between p35S::H2B.8-eGFP (Rep 2) and WT (Rep 2) between chromosome arms and pericentromeric regions over quantiles of seedling H2B.8 enrichment (log₂(IP/input)), as shown in Fig. 6c for Rep 1. Spearman’s ρ = 0.870.