Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 2;611(7936):532–539. doi: 10.1038/s41586-022-05377-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 6 — a. First principal component (PC1) of ARI genes identified in ASD exhibiting posteriorly downregulated (n = 1,881 genes, left) or upregulated (n = 1,695 genes, right) patterns of expression. Boxplots show median and interquartile range (25^th/75^th percentile; bounds of box) +/− 1.5 times the interquartile range (whiskers) for PC1 of these genes for each regional comparison, summarized across controls and dup15q samples (loess regression line plotted). The unique number of subjects per region is indicated in Fig.1. b. For each significantly attenuated regional comparison, the identified attenuated regional identity (ARI) genes. At center, number of ARI genes with greater neurotypical expression in each pair of regions. On either side of the barplot, the PC1 of the genes with greater neurotypical anterior (left) or posterior (right) expression is plotted across the pair of regions in Controls and ASD. The Wilcoxon signed-rank test (unpaired; two-tailed) p-value is shown. Boxplots show median and interquartile range (25^th/75^th percentile; bounds of box) +/− 1.5 times the interquartile range (whiskers) for PC1 of the genes for each regional comparison, summarized across controls and ASD samples, with the unique number of subjects per group x region comparison indicated in Fig. 1b.