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. 2022 Oct 19;611(7936):519–531. doi: 10.1038/s41586-022-05325-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a, Output of graph-based alignment of all chromosomes concatenated from all 45 HG002 assemblies (both haplotypes of diploid assemblies). Red vs Black, different orientations. Dendogram at bottom is a clustering of the alignments. b, HPRC v1.0 pipeline developed to produce the reference quality HPRC-HG002 v1.0 maternal and paternal assemblies. All steps shown are highlighted for the maternal data. The key steps of the pipeline are available in the Galaxy Server (https://assembly.usegalaxy.eu/) and best practices from this study at https://github.com/human-pangenomics/hpp_production_workflows/wiki/Assembly-Best-Practices.