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. 2022 Oct 19;611(7936):519–531. doi: 10.1038/s41586-022-05325-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Example Hi-C contact maps for bakeoff maternal (mat) and paternal (pat) haplotype assemblies. The Trio VGP scaffolded assembly has several dozen large joins and many small ones to make from the off-diagonal signals. The Trio hifiasm contig only assembly as expected has many more needed. b, Reference HPRC HG002 assemblies for each haplotype before and after manual curation, showing less off diagonal signals and no major scaffolds/contigs not placed in chromosomes after curation.