Table 3.
Multivariable Cox regression analysis of predictors for recurrence on the derivation set
| Variable | Preoperative model | Postoperative model | Interobserver agreement (95 CI%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | β | Point | Hazard ratio (95% CI) | p value | β | Point | ||||
| Tumor number | 0.653 (0.530, 0.777) | ||||||||||
| 1 | … | … | … | 0 | … | … | … | 0 | |||
| 2 or 3 | 2.615 (1.425, 4.799) | 0.002 | 0.961 | 9 | 2.257 (1.217, 4.187) | 0.010 | 0.814 | 8 | |||
| > 3 | 2.192 (1.098, 4.375) | 0.026 | 0.785 | 7 | 2.136 (1.038, 4.395) | 0.039 | 0.759 | 7 | |||
| Infiltrative appearance | 2.152 (1.046, 4.430) | 0.037 | 0.767 | 7 | 2.179 (1.091, 4.354) | 0.027 | 0.779 | 7 | 0.622 (0.474, 0.771) | ||
| Corona enhancement | 1.132 (0.660, 1.942) | 0.653 | 0.124 | 1 | NA | NA | NA | NA | 0.326 (0.174, 0.478) | ||
| AFP (> 400 ng/mL) | 1.811 (1.073, 3.058) | 0.026 | 0.594 | 5 | NA | NA | NA | NA | NA | ||
| AST (> 40 IU/L) | 2.960 (1.829, 4.793) | < 0.001 | 1.085 | 10 | 2.901 (1.799, 4.680) | < 0.001 | 1.065 | 10 | NA | ||
| Sex (male) | 1.906 (0.857, 4.238) | 0.114 | 0.645 | 6 | 2.522 (1.106, 5.750) | 0.028 | 0.925 | 9 | NA | ||
| MVI | NA | NA | NA | NA | 1.959 (1.155, 3.320) | 0.013 | 0.672 | 6 | NA | ||
| Tumor differentiation (poor) | NA | NA | NA | NA | 1.586 (0.978, 2.572) | 0.061 | 0.462 | 4 | NA | ||
AFP, alpha-fetoprotein; AST, aspartate aminotransferase; MVI, microvascular invasion; CI, confidence interval; NA, not applicable