Table 3.
Relative plasma levels of proteins extracted by principal component analysis.
| Symbol | Uniprot ID | Full name | Correlation PCA | FC AKI vs. no AKI | p-value | Adj. p-value |
|---|---|---|---|---|---|---|
| ADGRG1 | Q9Y653 | Adhesion G-protein coupled receptor G1 | PC1 | 1.48 | 0.156 | 0.285 |
| ATP6AP2 | O75787 | Renin receptor | PC2 | 1.06 | 1.000 | 0.982 |
| BAMBI | Q13145 | BMP and activin membrane-bound inhibitor homolog | PC2 | 1.45 | 0.021 | 0.093 |
| BANK1 | Q8NDB2 | B-cell scaffold protein with ankyrin repeats | PC1 | 1.26 | 0.433 | 0.547 |
| BID | P55957 | BH3-interacting domain death agonist | PC2 | 0.82 | 0.778 | 0.809 |
| BTC | P35070 | Probetacellulin | PC1 | 1.18 | 0.146 | 0.298 |
| CA12 | O43570 | Carbonic anhydrase 12 | PC1, PC2 | 1.52 | 0.007 | 0.042 |
| CA14 | Q9ULX7 | Carbonic anhydrase 14 | PC2 | 1.76 | 0.049 | 0.137 |
| CALCA | P06881 | Calcitonin gene-related peptide 1 | PC1 | 2.36 | 0.005 | 0.034 |
| CALR | P27797 | Calreticulin | PC1, PC2 | 1.36 | 0.002 | 0.022 |
| CLEC1A | Q8NC01 | C-type lectin domain family 1 member A | PC1, PC2 | 1.84 | 0.004 | 0.031 |
| DSG4 | Q86SJ6 | Desmoglein-4 | PC2 | 1.37 | 0.471 | 0.567 |
| EGFL7 | Q9UHF1 | Epidermal growth factor-like protein 7 | PC1 | 1.26 | 0.030 | 0.106 |
| ENAH | Q8N8S7 | Protein enabled homolog | PC1 | 1.25 | 0.219 | 0.352 |
| ENTPD6 | O75354 | Ectonucleoside triphosphate diphosphohydrolase 6 | PC1 | 1.25 | 0.300 | 0.454 |
| FABP9 | Q0Z7S8 | Fatty acid-binding protein 9 | PC2 | 1.27 | 0.093 | 0.197 |
| FES | P07332 | Tyrosine-protein kinase Fes/Fps | PC1, PC2 | 1.07 | 0.754 | 0.816 |
| FGR | P09769 | Tyrosine-protein kinase Fgr | PC1 | 1.08 | 0.639 | 0.736 |
| FOSB | P53539 | Protein fosB | PC1 | 1.22 | 0.076 | 0.168 |
| FOXO1 | Q12778 | Forkhead box protein O1 | PC1, PC2 | 1.08 | 0.379 | 0.515 |
| INPPL1 | O15357 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | PC1 | 1.21 | 0.300 | 0.442 |
| KIM1 | Q96D42 | Kidney Injury Molecule 1 | PC1 | 2.60 | < 0.001 | 0.008 |
| LAT2 | Q9GZY6 | Linker for activation of T-cells family member 2 | PC1 | 1.53 | 0.066 | 0.175 |
| LTA4H | P09960 | Leukotriene A-4 hydrolase | PC2 | 0.99 | 0.802 | 0.818 |
| MAEA | Q7L5Y9 | E3 ubiquitin-protein transferase MAEA | PC1 | 2.66 | 0.186 | 0.329 |
| MAP4K5 | Q9Y4K4 | Mitogen-activated protein kinase kinase kinase kinase 5 | PC1 | 0.68 | 0.285 | 0.444 |
| MVK | Q03426 | Mevalonate kinase | PC1, PC2 | 1.76 | 0.186 | 0.318 |
| NBN | O60934 | Nibrin | PC1 | 1.27 | 0.379 | 0.502 |
| NOS3 | P29474 | Nitric oxide synthase, endothelial | PC1 | 1.77 | 0.038 | 0.119 |
| NPPC | P23582 | C-type natriuretic peptide | PC1 | 4.67 | < 0.001 | 0.010 |
| NUB1 | Q9Y5A7 | NEDD8 ultimate buster 1 | PC1 | 1.16 | 0.471 | 0.555 |
| NUCB2 | P80303 | Nucleobindin-2 | PC2 | 1.76 | 0.002 | 0.019 |
| PDGFC | Q9NRA1 | Platelet-derived growth factor C | PC1 | 1.30 | 0.330 | 0.460 |
| PGF | P43088 | Prostaglandin F2-alpha receptor | PC2 | 1.81 | < 0.001 | 0.015 |
| PON2 | Q15165 | Serum paraoxonase/arylesterase 2 | PC2 | 0.98 | 0.802 | 0.802 |
| PRKAB1 | Q9Y478 | 5′-AMP-activated protein kinase subunit beta-1 | PC1 | 1.33 | 0.012 | 0.058 |
| PRKRA | O75569 | IFN-inducible dsRNA-dependent protein kinase activator A | PC1 | 1.02 | 0.754 | 0.799 |
| PTK7 | Q13308 | Inactive tyrosine-protein kinase 7 | PC2 | 1.67 | 0.008 | 0.043 |
| PTPRJ | Q12913 | Receptor-type tyrosine-protein phosphatase β | PC1 | 1.06 | 0.300 | 0.430 |
| PVALB | P20472 | Parvalbumin alpha | PC1 | 2.12 | 0.186 | 0.308 |
| PXN | P49023 | Paxillin | PC1 | 1.07 | 0.379 | 0.490 |
| RARRES1 | P49788 | Retinoic acid receptor responder protein 1 | PC1 | 1.33 | 0.023 | 0.087 |
| RASSF2 | P50749 | Ras association domain-containing protein 2 | PC1, PC2 | 0.96 | 0.684 | 0.771 |
| RRM2B | Q7LG56 | Ribonucleoside-diphosphate reductase subunit M2 B | PC1 | 2.13 | 0.021 | 0.086 |
| SERPINA9 | Q86WD7 | Serpin A9 | PC2 | 1.10 | 0.433 | 0.534 |
| ST3GAL1 | Q11201 | CMP-N-acetylneuraminate-β-galactosamide-α-2,3-sialyltransferase 1 | PC2 | 1.06 | 0.731 | 0.807 |
| STX8 | Q9UNK0 | Syntaxin-8 | PC1 | 1.53 | 0.033 | 0.110 |
| TIGAR | Q9NQ88 | Fructose-2,6-bisphosphatase | PC1 | 1.72 | 0.045 | 0.133 |
| TMPRSS15 | P98073 | Enteropeptidase | PC2 | 1.67 | 0.146 | 0.287 |
| TNNI3 | P19429 | Troponin I, cardiac muscle | PC1 | 3.22 | 0.071 | 0.164 |
| TOP2B | Q02880 | DNA topoisomerase 2-β | PC1 | 1.35 | 0.146 | 0.277 |
| VEGFC | P49767 | Vascular endothelial growth factor C | PC2 | 2.61 | 0.066 | 0.167 |
| YES1 | P07947 | Tyrosine-protein kinase Yes | PC1 | 1.39 | 0.066 | 0.159 |
Principal component analysis revealed 38 proteins to be correlated with PC1 and 22 proteins to be associated with PC2, of which nine proteins are different between AKI as compared to non-AKI controls (bold). AKI acute kidney injury, FC fold change.