Table 2.

Results of linear mixed-effects models fit with treatment, time, and baseline neuropsychological performance on cannabis grams per day.

Neuropsychological measure	Fixed effects	Estimate	SE	df	t	p
Grams per day
HVLT-R composite	Intercept	0.60	0.09	18.08	6.61	0.000***
	Treatment	−0.97	0.09	18.08	−1.06	0.30
	Time	0.18	0.05	17.06	3.43	0.003**
	HVLT-R	−0.02	0.11	33.10	−0.15	0.88
	Treatment x Time	0.07	0.05	17.06	1.33	0.20
	Treatment x HVLT-R	−0.17	0.11	33.10	−1.55	0.13
	Time x HVLT-R	−0.03	0.08	19.61	−0.49	0.63
	Treatment x Time x HVLT-R	−0.08	0.08	19.61	−1.00	0.32
SDR composite	Intercept	0.59	0.11	17.10	5.57	<0.001***
	Treatment	−0.10	0.11	17.10	−0.92	0.37
	Time	0.17	0.05	17.70	3.70	<0.001***
	SDR	<0.01	0.12	29.05	−0.07	0.92
	Treatment x Time	0.10	0.04	17.70	2.15	0.045*
	Treatment x SDR	−0.07	0.12	29.05	−0.68	0.50
	Time x SDR	0.23	0.08	18.40	2.84	0.01*
	Treatment x Time x SDR	−0.16	0.08	18.40	−1.97	0.06
CPT hit rate	Intercept	1.22	0.75	29.73	1.63	0.11
	Treatment	−0.82	0.75	29.73	−1.10	0.28
	Time	−0.62	0.46	20.03	−1.32	0.19
	CPT	<−0.01	<0.01	29.52	−0.81	0.42
	Treatment x Time	0.13	0.46	20.03	0.27	0.78
	Treatment x CPT	<0.01	<0.01	29.52	0.98	0.33
	Time x CPT	<0.01	<0.01	20.54	1.66	0.10
	Treatment x Time x CPT	<0.01	<0.01	20.54	−0.18	0.85
CPT attentional index	Intercept	0.64	0.08	19.74	7.84	<0.001***
	Treatment	−0.09	0.08	19.74	−1.16	0.81.26
	Time	0.18	0.06	18.43	3.01	0.007**
	CPT	0.12	0.05	27.15	2.62	0.01*
	Treatment x Time	0.07	0.06	18.43	1.26	0.22
	Treatment x CPT	−0.13	0.05	27.15	−2.82	0.009**
	Time x CPT	0.01	0.04	22.52	0.15	0.88
	Treatment x Time x CPT	−0.02	0.04	22.52	−0.49	0.61
TOL total correct	Intercept	−0.03	0.16	14.72	−0.19	0.029*
	Treatment	−0.64	0.16	14.72	−4.12	<0.001***
	Time	0.35	0.07	8.0	4.52	0.05*
	TOL	<0.001	<0.001	8.19	2.87	0.01*
	Treatment x Time	−0.30	0.07	8.02	−3.84	<0.001***
	Treatment x TOL	<−0.01	<0.001	8.19	5.75	<0.001***
	Time x TOL	<−0.01	<0.01	8.05	2.31	<0.05*
	Treatment x Time x TOL	<0.01	<0.001	8.05	5.29	<0.001***
TOL total moves	Intercept	−0.13	0.35	11.80	−0.36	0.72
	Treatment	0.26	0.35	11.80	−0.75	0.47
	Time	0.01	0.17	7.29	0.08	0.94
	TOL	<0.01	<0.01	10.85	1.43	0.18
	Treatment x Time	−0.51	0.17	7.29	−3.02	0.01**
	Treatment x TOL	<0.01	<0.01	10.85	1.08	0.30
	Time x TOL	<0.01	<0.01	7.32	0.96	0.36
	Treatment x Time x TOL	<0.01	<0.01	7.32	3.79	<0.006**
TOL problem solving time	Intercept	−1.12	0.75	15.96	1.49	0.15
	Treatment	−0.23	0.75	15.96	−0.30	0.77
	Time	−0.45	0.49	9.03	−0.92	0.38
	TOL	0.02	0.08	15.96	1.97	0.06
	Treatment x Time	−1.44	0.49	9.03	−2.91	0.017*
	Treatment x TOL	<0.01	0.08	15.96	0.40	0.69
	Time x TOL	<0.01	<0.01	8.80	1.26	0.24
	Treatment x Time x TOL	0.02	<0.01	8.80	3.09	0.013*
KDDT Geometric K	Intercept	0.81	0.36	25.78	2.25	0.03*
	Treatment	−0.29	0.36	25.78	−0.83	0.41
	Time	0.26	0.33	18.75	0.80	0.44
	KDDT	0.05	0.09	24.14	0.60	0.55
	Treatment x Time	0.18	0.33	18.75	0.56	0.58
	Treatment x KDDT	−0.06	0.09	24.14	−0.62	0.54
	Time x KDDT	0.02	0.08	18.78	0.27	0.79
	Treatment x Time x KDDT	0.03	0.08	18.78	0.32	0.75

Hopkins Verbal Learning Test (HVLT-R), the Spatial Delayed Response (SDR), Continuous Performance Test (CPT), Tower of London (TOL), Kirby Delayed Discounting Task (KDDT).

Bold values in the table represent significant interactions of interest (p < 0.05)

*p < 0.05; **p < 0.01; ***p < 0.001