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. 2022 Nov 16;12:19660. doi: 10.1038/s41598-022-24137-1

Figure 8.

Figure 8

ARG inhibitors reduce bortezomib-induced cardiotoxicity. (A) Plasma nitrite (NO2-) concentrations in C57BL/6 mice treated with 100 mg/kg i.p. INCB01158 were measured on day 7. Data show means ± SD; n = 5–7; P-values vs ctrl were calculated with one-way ANOVA with Dunnett’s post hoc test, n = 5. (B) Left ventricle ejection fractions (LVEF) measured with echocardiography in C57BL/6 mice on day 7 of bortezomib (1 mg/kg i.p.) and/or INCB01158 (100 mg/kg p.o. twice daily) treatment; graphs present means ± SD; n = 4–5; P-values were calculated with one-way ANOVA with Tukey’s post-hoc test.