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. 2022 Nov 16;5:1255. doi: 10.1038/s42003-022-04212-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative images of CB5600 (wt) with GFP tagged mitochondria which displayed a well organised mitochondrial network. CC91 (dys-1(eg33) with GFP tagged mitochondria which showed a severely disorganised mitochondrial network. L-homocysteine (10 µM), L-cysteine (10 µM), L-glutathione (100 µM) and L-taurine (10 µM), all significantly improved the proportion of well-networked mitochondria, and also reduced the degree of disorganised networks to dys-1(eg33) animals, but not to wt levels. L-Methionine (10 mM) did not significantly increase well-networked proportions, but did offset the prevalence of disorganised networks to dys-1(eg33). b A stacked bar graph showing the percentage of well-networked, moderately well-networked and disorganised network within each group. Scale bar: 30 µm. Data are means from 20 animals across two biological repeats.