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. 2022 Nov 3;15:1037929. doi: 10.3389/fnmol.2022.1037929

FIGURE 3.

FIGURE 3

Distribution of dysregulated non-coding RNAs (ncRNAs) with the respective associated targets in diabetic neuropathic pain (DNP): ncRNAs (including microRNA, circular RNA, and long non-coding RNA) can participate in the development of DNP through various targets and mechanisms. NcRNAs displays different expressions in DRG, spinal cord and sciatic nerve of DNP models in DNP. DRG, dorsal root ganglion; HMGB1, high mobility group box-1; IL, interleukin; MAPK, mitogen-activated protein kinases; Nrf2, nuclear factor erythroid 2-related factor 2; RAP1A, Ras-associated protein-1 A; TNF, tumor necrosis factor; TRPV1, transient receptor potential vanilloid 1.