TABLE 1.
Non-coding RNAs in periphery neuropathic pain (including PNI and DNP).
| Classification | Model | ncRNAs | Expression | Tissue | Target | PMID |
| MiRNA | SNI | miR-30c-5p | Up | SC, DRG, CSF, and plasma | TGF-β | 30089634 |
| SNL | miR-143 | Down | DRG | Dnmt3a | 29170626 | |
| miR-21 | Up | DRG | TLR8 | 30455267 | ||
| miR-124-3p | Down | DRG/SDH | Egr1 | 34008206 | ||
| CCI | miR-206-3p | Down | DRG | HDAC4 | 30587671 | |
| miR-223 | Down | SC | NLRP3/IL-1β | 34408803 | ||
| MiR-144 | Down | DRG | RASA1 | 31737949 | ||
| miR-140-3p | Down | DRG | JAG1 | 34269482 | ||
| miR-122-5p | Down | SC | PDK4 | 33566299 | ||
| miR-30b-5p | Down | SC | CYP24A1-Wnt/beta-catenin signaling | 34748047 | ||
| miR-340-5p | Down | SC | Rap1A | 30848438 | ||
| miRNA-146a-5p | Up | DRG and SDH | IRAK1/TRAF6 | 29885668 | ||
| DNP | miR-190a-5p | Down | SC | SLC17A6 | 29042815 | |
| miR-155 | Up | SC | Nrf2 | 31404910 | ||
| miR-193a | Down | Lumbar SDH | HMGB1 | 31665716 | ||
| miR-590-3p | Down | DRG | RAP1A | 33332780 | ||
| miR-133a-3p | Up | SN | p38MAPK | 32632603 | ||
| CircRNA | SNI | circRNA.2837 | Down | SN | miR-34 family members | 30098504 |
| SCiatic nerve crush model | circAnkib1 | Down | SN | miR-423-5p, miR-485-5p, miR-666-3p/Cyp26b1 | 31415184 | |
| CCI | CIRCZNF609 | Unknown | Unknown | miR-22-3p/ENO1 | 32827683 | |
| circ_0005075 | Up | DRG | miR-151a-3p/NOTCH2 | 32860901 | ||
| ciRS-7 | Up | SDH | miR-135a-5p | 31978512 | ||
| circZRANB1 | Down | SC | miR-24-3p/LPAR3 | 32777532 | ||
| circRNA_013779 | Up | SDH | Unknown | 28761373 | ||
| circRNA_008008 | Up | SDH | Unknown | |||
| circRNA_003724 | Up | SDH | Unknown | |||
| DNP | circHIPK3 | Up | DRG | miR-124 | 30286957 | |
| mmu_circ_0010794 | Up | SC | Unknown | 34055074 | ||
| mmu_circ_0006623 | Up | SC | Unknown | |||
| mmu_circ_0006175 | Up | SC | Unknown | |||
| mmu_circ_0016083 | Down | SC | Unknown | |||
| mmu_circ_0006471 | Down | SC | Unknown | |||
| LncRNA | SNI | lncRNA DGCR5 | Down | SC | miR-330-3p/PDCD4 | 30317600 |
| lncRNA LOC100911498 | Up | SC | P2X4R, BDNF, p38 | 33949153 | ||
| lncRNA Linc01119 | Up | SC and DRG | ELAVL1/BDNF | 34234645 | ||
| SNL | lncRNA SNHG1 | Up | SC | CDK4 | 33336721 | |
| lncRNA SNHG4 | Up | SC | miR-423-5p | 32454787 | ||
| lncRNA SNHG5 | Up | DRG | miR-154-5p/CXCL13 | 32248399 | ||
| lncRNA H19 | Up | DRG | Unknown | 32099850 | ||
| lncRNA PKIA-AS1 | Up | SC | CDK6 | 30873006 | ||
| Linc00052 | Up | SC | miR-448/JAK1 | 32012267 | ||
| lncRNA Lncenc1 | Up | DRG | EZH2/BAI1 | 33340495 | ||
| CCI | lncRNA FIRRE | Up | SC | HMGB1 | 33151463 | |
| lncRNA XIST | Up | SC | miR-154-5p/TLR5 | 30335888 | ||
| Up | SC | miR-150/ZEB1 | 29323698 | |||
| Up | SC | miR-544/STAT3 | 29219175 | |||
| lncRNA MALAT1 | Up | SC | miR-129-5p/HMGB1 | 32065547 | ||
| Up | SC | miR-154-5p/AQP9 | 31746418 | |||
| lncRNA CRNDE | Up | SC | miR-136/IL-6R | 34612146 | ||
| lncRNA DILC | Up | SC | SOCS3/JAK2/STAT3 | 32510145 | ||
| lncRNA uc.153 | Up | SC | miR-182-5p/EphB1-NMDA | 32701835 | ||
| LncRNA NEAT1 | Up | SC | miR-381/HMGB1 | 29633273 | ||
| lncRNA SNHG16 | Up | SC | miR-124-3p, miR-141-3p/JAG1 | 33049352 | ||
| lncRNA GAS5 | Down | SC | miR-452-5p/CELF2 | 33264082 | ||
| lncRNA MRAK009713 | Up | DRG | P2X3 | 28708759 | ||
| DNP | lncRNA NON-RATT021972 | Up | DRG | P2X7 | 28928602 | |
| lncRNA uc.48+ | Up | DRG | P2X3 | 26686228 | ||
| lncRNA BC168687 | Up | DRG | P2X7 | 29204447 | ||
| Up | DRG | TRPV1 | 29421435 | |||
| lncRNA ENSMUST00000150952 | Down | SDH | Mbp | 30599267 | ||
| lncRNA AK081017 | Down | SDH | Usp15 |
AQP, amniotic aquaporins; BAI1, brain angiogenesis inhibitor 1; BDNF, brain-derived neurotrophic factor; CCI, chronic constriction injury; CDK, cyclin-dependent kinase; CELF2, CUGBP Elav-like family member 2; CSF, cerebrospinal fluid; DNP, diabetic neuropathic pain; DRG, dorsal root ganglion; ELAVL1, ELAV-like RNA-binding protein 1; ENO1, Alpha-enolase; EphB1, Eph receptor B1; EZH, Zeste homolog; HDAC4, histone deacetylase 4; HMGB1, high mobility group box-1; IRAK1, interleukin-1 receptor-associated kinases 1; JAG1, Jagged1; JAK, Janus kinase; LPAR3, lysophosphatidic acid receptor 3; MAPK, mitogen-activated protein kinases; NLRP3, NOD-like receptor family pyrin domain containing 3; NMDA, N-methyl-d-aspartate; Nrf2, nuclear factor erythroid 2-related factor 2; PDCD4, programmed cell death factor-4; PDK4, pyruvate dehydrogenase kinase 4; PNI, peripheral nerve injury; P2XR, P2X receptor; RAP1A, Ras-associated protein-1 A; SC, spinal cord; SDH, spinal cord dorsal horn; SNL, spinal nerve ligation; SNI, spared sciatic nerve injury; SN, sciatic nerve; STAT3, signal transducer and activator of transcription 3; TGF-β, Transforming growth factor-β; TRAF, TNF receptor associated factor; TRPV1, transient receptor potential vanilloid 1; ZEB1, Zinc finger E-box binding homeobox 1.