TABLE 4.
Probe-wise mediation analysis of the relationship between childhood trauma burden (CTQ total) and rostral middle frontal gyrus (RMFG) surface area (SA).
Probe name | Module name | Chr:pos (hg38) | Gene name | IDE β | IDE P | DE β | DE P | TE β | TE P |
cg21622733 | Maroon | Chr19:35408551 | LINC01531 | −0.512 | 0.003** | −0.471 | 0.320 | −0.983 | 0.044* |
cg19805668 | Maroon | Chr14:74951972 | PGF | −0.411 | 0.009** | −0.592 | 0.217 | −1.003 | 0.042* |
cg10592766 | Maroon | Chr19:50226846 | MYH14 | −0.321 | 0.019* | −0.670 | 0.182 | −0.990 | 0.048* |
cg03710029 | Maroon | Chr17:81291801 | SLC38A10 | −0.383 | 0.025* | −0.613 | 0.188 | −0.996 | 0.043* |
cg15150970 | Maroon | Chr2:25250660 | DNMT3A | −0.253 | 0.049* | −0.753 | 0.125 | −1.006 | 0.040* |
cg12219789 | Maroon | Chr17:7324180 | NEURL4 | −0.352 | 0.049* | −0.622 | 0.183 | −0.974 | 0.049* |
cg01544227 | White | Chr12:8323720 | AC092745.5 | −0.305 | 0.036* | −0.689 | 0.175 | −0.994 | 0.044* |
cg00686169 | White | Chr8:8024026 | FAM90A24P | −0.277 | 0.043* | −0.740 | 0.126 | −1.017 | 0.037* |
cg08002107 | White | Chr8:12135255 | USP17L7 | −0.268 | 0.047* | −0.738 | 0.122 | −1.006 | 0.040* |
***P < 0.001, **P < 0.01, *P < 0.05, P: BH-significant (bold). Both dependent and independent variables were scaled prior to analysis. IDE, indirect effect; DE, direct effect; TE, total effect; β, coefficient estimate; P, nominal p-value; BH, Benjamini-Hochberg.