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. 2022 Nov 3;13:1057746. doi: 10.3389/fimmu.2022.1057746

Figure 1.

Figure 1

Diabetes aggravates CYP-induced cystitis. (A) Schematic of experiment: STZ was used at D0 to develop diabetes in mice. After 6 days when diabetes was confirmed, experimental cystitis was induced by 4 i.p. injection of CYP on D6, 8, 10 and 12. Von Frey test was done at D13, and mice were sacrificed at D16 for end assessments. (B-F) Four groups of mice were used. Group 1: mice received i.p. saline (control for STZ) at D0 and i.p. saline (control for CYP) at D6, 8, 10 and 12 (saline+saline); Group 2: mice received i.p. STZ at D0 and i.p. saline (control for CYP) at D6, 8, 10 and 12 (STZ+saline); Group 3: mice received i.p. saline (control for STZ) at D0 and i.p. CYP at D6, 8, 10 and 12 (saline+CYP); Group 4: mice received i.p. STZ at D0 and i.p. CYP at D6, 8, 10 and 12 (STZ+CYP). (B) Nociceptive score of the mice at Von Frey test at D13. (C) Changes in body weight. (D) Bladder weight at D16. (E) Edema score of the bladder at D16. (F) Vesical vascular permeability in bladder at D16. *p<0.05 (STZ+CYP vs saline+CYP). #p<0.05 (saline+CYP vs saline+saline or STZ+saline).