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. 2022 Nov 3;13:1057746. doi: 10.3389/fimmu.2022.1057746

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Copyright © 2022 Peng and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NLRP3 significantly increases in bladder macrophages in diabetic mice that undergo cystitis. (A, B) Mouse bladders were sorted for bladder macrophages based on positivity for F4/80, and further for M1 (CD163-) and M2 (CD163+) subtypes among all F4/80+ macrophages, shown by representative flow charts (A) and by quantification (B). (C) ELISA for some critical factors for macrophage phenotype and functionality. *p<0.05. ns: no significance.