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. 2022 Nov 16;12:19642. doi: 10.1038/s41598-022-21900-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Diffuse mHTT reduction in the cortex (6A,6B) and striatum (6C,6D). Compared to a vehicle (veh), administration of GLYN122 reduced diffuse mHTT in the cortex by 40% in the nucleus (6A) and by 45% in the cytoplasm of treated TG mice (* p = 0.01 and p = 0.02, respectively). Likewise, GLYN122 reduced diffuse mHTT in the striatum by 40% in the nucleus (6C) and 43% in the cytoplasm (6D) compared to vehicle (veh) of treated TG mice (p = 0.14 and p = 0.06, respectively). The points on the graph represent different samples of the same animals.

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