Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 3;9:1043165. doi: 10.3389/fcvm.2022.1043165

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Semenova, Zabirnyk, Lobov, Boyarskaya, Kachanova, Uspensky, Zainullina, Denisov, Gerashchenko, Kvitting, Kaljusto, Thiede, Kostareva, Stensløkken, Vaage and Malashicheva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Comparison of proteomic and transcriptomic profiles of human valve interstitial cells (VIC) from patients with or without calcific aortic valve disease (CAVD) in standard cultivation (control) and in osteogenic medium (differentiated). (A) Venn diagram shows the number of unique gene products identified by shotgun proteomics and RNA-seq transcriptomics. (b-c) Partial least squares-discriminant analysis (PLS-DA) score plots based on transcriptomic (B) and proteomic (C) data. Yellow triangles—differentiated VIC from patients with CAVD, green crosses—differentiated VIC from healthy donors, gray pluses—control VIC from healthy donors, blue circles—control VIC from patients with CAVD.