Table 3.
Hazard ratios (HRs) for the association of TyG index or CRP levels with CRC risk.
| Group | Cases/person-years | Crude models | Adjusted models | ||
|---|---|---|---|---|---|
| HR (95%CI) | p-value | HR (95%CI) | p-value | ||
| TyG index (continuous) | 586/1145910 | 1.32 (1.17,1.47) | <0.001 | 1.21 (1.06,1.37) | 0.006 |
| TyG index (median) | |||||
| < 8.59 | 228/572835 | Ref. | Ref. | ||
| ≥ 8.59 | 358/573075 | 1.57 (1.33,1.84) | <0.001 | 1.41 (1.17,1.67) | <0.001 |
| P for interactiona | 0.048 | ||||
| CRP (continuous) | 586/1145910 | 1.01 (1.00,1.02) | 0.128 | 1.00 (0.99,1.01) | 0.758 |
| CRP | |||||
| < 1 mg/L | 291/672247 | Ref. | Ref. | ||
| 1-3 mg/L | 162/277672 | 1.36 (1.12,1.65) | 0.002 | 1.17 (0.97,1.43) | 0.109 |
| >3 mg/L | 133/195992 | 1.59 (1.29,1.95) | <0.001 | 1.29 (1.05,1.60) | 0.017 |
| P for trend | <0.001 | 0.042 | |||
Adjusted models were adjusted for age (every 10 years), sex, family income, educational background, WC, TC, smoking status, drinking status, physical activity, sedentary lifestyle, tea consumption, high-fat diet, hypertension, diabetes, and family history of cancer.
aInteraction between TyG index and CRP for the risk of CRC.