Table 4. Sequence kernel association tests of low frequency and rare ENaC variants with eGFR.

SKAT was performed on variants with a MAF < 0.05 in the genomic regions of SCNN1A, SCNN1B, SCNN1D, and SCNN1G with eGFR, separately, and then combined. SKAT was separately performed on rare (MAF < 0.01) and low frequency (0.01 ≤ MAF < 0.05) variants. Significant p values are in bold.

Gene. Chromosome:Start–End	Variants with MAF < 0.05		Variants with MAF < 0.01		Variants with 0.01 ≤ MAF < 0.05
	n	p value	n	p value	n	p value
SCNN1A. 12:6346824–6379751	2,739	0.01	2,626	0.008	113	0.07
SCNN1B. 16:2329812–23381320	8,770	0.005	8,365	0.007	405	0.03
SCNN1D. 1:1280417–1292050	1,758	0.002	1,648	0.2	110	0.001
SCNN1G. 16:23184696–23216904	2,868	0.1	2,797	0.01	71	0.1
Combined (SCNN1A, SCNN1B, SCNN1D, SCNN1G)	16,135	0.0003	15,436	0.002	699	0.003

^*p values < 0.00625 are significant