Table 5. Sequence kernel association tests of low frequency and rare ENaC variants with stroke.

SKAT was performed on variants with a MAF < 0.05 in the genomic regions of SCNN1A, SCNN1B, SCNN1D, and SCNN1G with stroke, separately, and then combined. SKAT was separately performed on rare (MAF < 0.01) and low frequency (0.01 ≤ MAF < 0.05) variants.

Gene. Chromosome:Start–End	Variants with MAF < 0.05		Variants with MAF < 0.01		Variants with 0.01 ≤ MAF < 0.05
	n	p value	n	p value	n	p value
SCNN1A. 12:6346824–6379751	2,330	0.08	2,216	0.05	114	0.2
SCNN1B. 16:2329812–23381320	6,965	0.5	6,556	0.7	409	0.4
SCNN1D. 1:1280417–1292050	1,621	0.5	1,497	0.6	124	0.4
SCNN1G. 16:23184696–23216904	2,208	0.2	2,137	0.1	71	0.3
Combined (SCNN1A, SCNN1B, SCNN1D, SCNN1G)	13,124	0.3	12,406	0.3	718	0.3