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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Hypertension. 2022 Aug 12;79(11):2409–2418. doi: 10.1161/HYPERTENSIONAHA.122.18567

Figure 4: Role of polymerizing and non-polymerizing uromodulin in context of site of action.

Figure 4:

These functions are based on a summary of the literature in experimental and clinical setting. The role of uromodulin likely depends on the form and abundance of uromodulin, the site of interaction and the cell type(s) involved. Thick ascending limb, TAL; Distal convoluted tubule (DCT); Connecting tubule (CNT).