Table 1:

Summary of sex distribution among each major PD group, and separately among GBA-variant severities

Among PD groups
Cohort	N	Women (N, % cohort)	Men (N, % cohort)	p-value
Idiopathic PD	420	153 (36.4%)	267 (63.6%)	<0.001
LRRK2 PD	99	49 (49.5%)	50 (50.5%)	0.920
LRRK2/GBA PD	10	5 (50.0%)	5 (50.0%)	1.00
GBA PD	107	43 (40.2%)	64 (59.8%)	0.042
Among GBA-variant severities
Severe GBA PD	19	15 (79.0%)	4 (21.1%)	0.005
Mild GBA PD	70	26 (37.1%)	44 (62.9%)	0.377
Risk-variant GBA PD	17	2 (11.8%)	15 (88.2%)	0.002

Within group summary of sex distribution in PD overall and in the different genetic groups. Although idiopathic PD and GBA PD are more likely to be men, LRRK2 PD and LRRK2/GBA PD were not. Further, carriers of a severe GBA variant were more likely to be women, unlike carriers of a mild GBA variant, who were more likely to be men. One GBA PD among men was screened as part of an outside study and they were excluded from the variant-specific analysis. Verification of GBA variant status for this participant using our cohort’s methods is ongoing.