Table 2:

Regression analysis of sex distribution among each major PD group and separately among GBA-variant severities

Model comparing odds of being a woman among PD groups
Cohort	OR (95% CI)	p-value
LRRK2 PD vs Idiopathic PD	1.71 (1.10–2.66)	0.017
LRRK2 PD vs LRRK2/GBA PD	0.98 (0.27–3.60)	0.976
LRRK2/GBA PD vs Idiopathic PD	1.75 (0.50–6.12)	0.385
GBA PD vs Idiopathic PD	1.17 (0.76–1.81)	0.473
GBA PD vs LRRK2 PD	0.69 (0.39–1.19)	0.180
GBA PD vs LRRK2/GBA PD	0.67 (0.18–2.46)	0.548
Model comparing odds of being a woman including GBA-variant severities
Cohort	OR (95% CI)	p-value
Severe GBA PD vs Idiopathic PD	6.54 (2.13–20.07)	0.001
Severe GBA PD vs LRRK2 PD	3.83 (1.19–12.34)	0.025
Severe GBA PD vs LRRK2/GBA PD	3.75 (0.71–19.71)	0.118
Severe GBA PD vs Mild GBA PD	6.35 (1.90–21.17)	0.003
Severe GBA PD vs Risk-variant GBA PD	28.12 (4.46–177.46)	<0.001
Mild GBA PD vs Idiopathic PD	1.03 (0.61–1.74)	0.909
Mild GBA PD vs LRRK2 PD	1.66 (0.88–3.10)	0.112
Mild GBA PD vs LRRK2/GBA PD	0.59 (0.16–2.24)	0.439
Mild GBA PD vs Risk-variant GBA PD	4.43 (20.94–0.94)	0.060
Risk-variant GBA PD vs Idiopathic PD	0.23 (0.05–1.03)	0.055
Risk-variant GBA PD vs LRRK2 PD	0.14 (0.03–0.92)	0.010
Risk-variant GBA PD vs LRRK2/GBA PD	0.13 (0.02–0.92)	0.040

Two models estimating odds ratios, comparing odds of being a woman between groups. As was expected, LRRK2 PD were more likely to be women than idiopathic PD (OR, SE: 1.71, 1.10–2.66; p=0.017). Although the odds of being a woman were not different between GBA PD and idiopathic PD (OR, SE: 1.17, 0.76–1.81; p=0.473) or GBA PD and LRRK2 PD (OR, SE: 0.69, 0.39–1.19; p=0.180), severe GBA PD were more likely to be women than both idiopathic PD (6.54, 2.13–20.07; p=0.001), LRRK2 PD (3.83, 1.19–12.34; p=0.025), and even mild GBA PD (6.35, 1.90–21.17; p=0.003).