Figure 3. Fibγ^390-396A mice are protected, Fib^AEK and FXIII- mice partially protected, and Fib- mice are not protected from developing NAFLD when challenged with HFD.

(A) Total liver mass, (B) level of hepatic triglyceride and (C) alanine transferase (ALT) activity in plasma of Fibγ^WT and Fibγ^390-396A mice. (D) Representative H&E-stained sections of livers isolated from Fibγ^WT and Fibγ^390-396A mice. (E) Total liver mass, (F) level of hepatic triglyceride and (G) ALT activity in plasma of Fib+ and Fib- mice. (H) Representative H&E-stained sections of livers isolated from Fib+ and Fib- mice. (I) Total liver mass, (J) level of hepatic triglyceride and (K) ALT activity in plasma of Fib^WT and Fib^AEK mice. (L) Representative H&E-stained sections of livers isolated from Fib^WT and Fib^AEK mice. (M) Total liver mass, (N) level of hepatic triglyceride and (O) ALT activity in plasma of FXIII+ and FXIII- mice. (P) Representative H&E-stained sections of livers isolated from FXIII+ and FXIII- mice. Magnification: 20X. Scale bar: 40 μm. Data are expressed as mean±SEM and analyzed by 2-way ANOVA with Fisher’s LSD test. *P<0.05, **P<0.01, ***P<0.001. LFD: n=4–7; HFD: n=6–12