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. Author manuscript; available in PMC: 2023 Nov 14.
Published in final edited form as: Cancer Cell. 2022 Sep 8;40(11):1294–1305.e4. doi: 10.1016/j.ccell.2022.08.008

Figure 4: OFF VIPER CAR prevents CRS in an in vivo CRS SCID-beige mouse model.

Figure 4:

A) Timeline of the in vivo experiment. B) Cytokines (hIFN—γ, hGM-CSF, hIL-2, and hIL-3) detected in the blood 24 hours post T cell injection via Luminex assay. (mean ± s.d., n = 3, *P < 0.05, **P < 0.01 and ***P < 0.001). C) Kaplan-Meier survival curves were drawn between 0–120 hours post T cell injection for the various treatment groups. (Dasa: dasatinib)