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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Oncogene. 2022 Oct 11;41(46):4983–4993. doi: 10.1038/s41388-022-02492-7

Figure 3. Stat3 knockdown in melanoma cell lines partially restores IFN-related gene expression without affecting intrinsic cell growth.

Figure 3.

(a) Lentiviral shRNA Stat3 knockdown (KD) in melanoma cell lines confirmed by qPCR (left) and by Western blot (***p<0.001). Control shRNA targets the luciferase gene.

(b) Expression of interferon-related genes in control and shRNA Stat3 knockdown. Data were averaged from triplicate experiments (*p<0.05, **p<0.01).

(c) Effect of shRNA Stat3 knockdown in Ezh2Y641F melanoma cell growth in vitro.