Table 1.
Disorders Associated with Changes in Uric Acid
| Condition | Serum UA |
|---|---|
|
| |
| Neurodegenerative diseases | |
| Parkinson’s disease | − |
| Alzheimer’s disease | − |
| Motor neuron disease | − |
|
| |
| Inflammatory disorders | |
| Gouty arthritis | + |
| Asthma | + |
| Autoimmune disease | − |
| Multiple sclerosis | − |
|
| |
| Vascular disease | |
| Coronary artery disease | + |
| Stroke | + |
| Vascular dementia | + |
|
| |
| Other disorders | |
| Hypertension | + |
| Diabetes mellitus | + |
| Metabolic syndrome | + |
| Hemolytic anemia | + |
| Leukemia | + |
| Renal insufficiency | − |
| Fanconi disease | − |
|
| |
| Inherited diseases | |
| Lesch-Nyhan disease | + |
| Down syndrome | + |
| Fructosemia | + |
| Glycogen storage diseases | + |
| APRT deficiency | + |
| PRPPS overexpression | + |
| Familial hyperuricemic nephropathy | − |
| Hereditary xanthinurias | − |
| Renal hypouricemia | − |
|
| |
| Medications/supplements | |
| Diuretics | + |
| Cyclosporin | + |
| Androgens | + |
| Aspirin | + |
| Fructose | + |
This table shows the direction of serum uric acid (UA) found in the conditions listed, with (+) higher than healthy controls and (−) lower than healthy controls.