Figure 5. Ability of the metrics to detect cardiac dysfunction in rats (mean ± SD).
Ees(IVC), end-systolic elastance obtained from inferior vena cava occlusion (IVCO), Ees(SB1), left ventricular (LV) end-systolic pressure (LVESP) and end-systolic volume (ESV) ratio; PRSW(IVC), preload recruitable stork work obtained from IVCO; PRSW(SB), stroke work (SW) and end-diastolic volume (EDV) ratio; PWRmax-EDV, maximal power (PWRmax) and EDV ratio; PWRmax-EDV2, PWRmax and squared of EDV ratio; LVEFEA1, afterload adjusted left ventricular ejection fraction using ventricular data; dP/dtmax-EDV(IVC), the relationship between the maximal rate of rise of pressure and EDV obtained from IVCO; LVdP/dtmax-EDV, the maximal rate of rise of the left ventricular pressure (LVdP/dtmax) and EDV ratio; Pmax-EDV, maximal pressure (Pmax) and EDV ratio; LVESP-EDV, LVESP and EDV ratio. Note that 2 control groups of animals were used as the myocardial infarction (MI) outcomes were assessed open-chest whereas in the animal with absent bulbospinal sympathetic control (SNX) the outcomes were assessed closed-chest. Statistical analysis was performed using either independent t-test or Mann-Whitney tests (SNX, n = 16; MI, n = 10). Note that given no peripheral catheterization was performed in the MI experiment, we have not calculated any indices of cardiac contractility from arterial data; therefore, only metrics derived from LV data are illustrated. Statistical findings for indices derived from arterial data in an animal model of spinal cord injury are found in the Statistical Summary Document.