Table 4:

Associations between clinical risk factors included in the modified ARVC risk calculator and 5-year VA event risk. Hazard ratios are presented with 95% confidence intervals.

	Cox proportional hazards regression using baseline variables Hazard ratios [95% CI]				Time varying Cox regression Hazard ratios [95% CI]
Variable	Univariable	p-value	Multivariable	p-value	Univariable	p-value	Multivariable	p-value
Age (years) (per year)	0.983 [0.972; 0.995]	0.004	0.978 [0.966; 0.989]	<0.001	0.983 [0.972; 0.995]	0.004	0.983 [0.971; 0.994]	0.003
Male sex (vs. female)	1.843 [1.307; 2.600]	<0.001	1.746 [1.234; 2.471]	0.002	1.843 [1.307; 2.600]	<0.001	1.730 [1.222; 2.449]	0.002
Presence of NSVT (vs. absence)	3.653 [2.434; 5.484]	<0.001	2.126 [1.350; 3.347]	0.001	3.012 [2.082; 4.356]	<0.001	1.758 [1.165; 2.652]	0.007
History of cardiac syncope (vs. absence)	2.197 [1.504; 3.209]	<0.001	1.554 [1.050; 2.298]	0.027	2.470 [1.713; 3.562]	<0.001	1.794 [1.232; 2.612]	0.002
# TWI (per lead)	1.199 [1.107; 1.297]	<0.001	1.100 [1.004; 1.206]	0.04	1.176 [1.090; 1.269]	<0.001	1.079 [0.994; 1.171]	0.071
log(24 hour PVC count)	1.536 [1.366; 1.729]	<0.001	1.321 [1.156; 1.510]	<0.001	1.381 [1.243; 1.533]	<0.001	1.207 [1.080; 1.348]	0.001
Presence of mod./sev. RV dysfunction (vs absence)	2.745 [1.922; 3.920]	<0.001	1.421 [0.968; 2.084]	0.073	2.961 [2.076; 4.225]	<0.001	1.807 [1.239; 2.637]	0.002