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Alpha and beta diversity of microbiota associated with log2 serum 7αC4 (upper panel) and per cent primary BAs in stool (lower panel). Patients with higher serum 7αC4 and higher per cent primary BAs had significantly lower alpha diversity. There was a significantly different microbial compositional profile based on beta diversity between participants with higher and lower markers of ABAM based on both parameters of ABAM. ABAM, abnormal bile acid metabolism; BAs, bile acids.
