Table 1.
Demographics and biochemical features of patients with IBS-D without ABAM and patients with BAD. Data shown are median (IQR)
| IBS-D without ABAM (N=161) | Bad (N=44) | P value | |
|---|---|---|---|
| Demographics | |||
| Age (years) | 37 (26, 50) | 46 (35, 58) | 0.01 |
| BMI (kg/m2) | 28.6 (23.5, 33.9) | 33.9 (29.9, 38.5) | <0.001 |
| % female | 77.6% | 81.4% | |
| Bile acid indices | |||
| Serum FGF-19 (pg/mL) | 103.4 (63.9, 170.5) | 59.1 (30.2, 102.2) | <0.001 |
| Serum 7αC4 (ng/mL) | 19.8 (9.9, 30.9) | 74.3 (61.1, 93.7) | <0.001 |
| Total faecal bile acids (μmol/g stool) | 2.1 (1.2, 3.5) | 3.8 (2.5, 5.1) | <0.001 |
| % faecal 1° BAs (CDCA+CA) | 1.3 (0.7, 4.3) | 15.0 (1.2, 39.8) | <0.001 |
| SCFAs in stool | |||
| Faecal acetic acid (nmol/mg) | 35.2 (25.6, 48.4) | 36.0 (27.6, 49.6) | 0.85 |
| Faecal propionic acid (nmol/mg) | 6.8 (4.7, 10.1) | 7.2 (5.4, 11.6) | 0.39 |
| Faecal isobutyric acid (nmol/mg) | 2.2 (1.6, 3.1) | 1.9 (1.1, 3.0) | 0.15 |
| Faecal isovaleric acid (nmol/mg) | 1.8 (1.2, 2.6) | 1.6 (0.8, 2.4) | 0.37 |
| Faecal valeric acid (nmol/mg) | 0.7 (0.5, 1.0) | 0.6 (0.2, 1.0) | 0.32 |
| Faecal isocaproic acid (nmol/mg) | 0.05 (0.03, 0.07) | 0.04 (0.02, 0.09) | 0.75 |
| Faecal hexanoic acid (nmol/mg) | 0.08 (0.04, 0.24) | 0.06 (0.03, 0.10) | 0.014 |
Isobutyric acid is similar to butyric acid ((CH3)2-CH-COOH).
P values are based on Wilcoxon rank sum test.
ABAM, abnormal bile acid metabolism; BAD, bile acid diarrhoea; BAs, bile acids; BMI, body mass index; CA, cholic acid; CDCA, chenodeoxycholic acid; FGF-19, fibroblast growth factor-19; IBS-D, irritable bowel syndrome with diarrhoea; SCFAs, short chain fatty acids; 7αC4, 7α-hydroxy-4-cholesten-3-one.