Table 4.

Differential gene expressions in ascending colon biopsies of BAD and IBS-D without ABAM

Gene symbol	Full name of gene	Gene function	Log2 fold change	Padj value	DE
Permeability/barrier
CLDN2	Claudin 2	Exclusively in tight junction: Barrier function	1.737	0.007	Up
GALNT15	Polypeptide N-Acetylgalactos-aminyltransferase 15	Mucin type O-glycan biosynthesis in goblet cells	−1.019	0.025	Down
Serine/cysteine protease activity
SPINK4	Serine Protease Inhibitor, Kazal Type 4	Serine-type endopeptidase inhibitor	1.607	0.002	Up
SERPINB5	Serpin Family B Member 5	Serine protease inhibitor	1.725	0.007	Up
CAPN6	Calpain 6	Ca++-dependent, cysteine proteases	1.185	0.031	Up
Inflammation or immune function
C4BPB	Complement component 4- binding protein beta chain	Control of complement activation, eg, degradation of C3 convertase	1.208	0.002	Up
CCL25	C-C Motif Chemokine Ligand 25	Chemokine in T cell development	2.451	0.014	Up
CXCL5	C-X-C motif chemokine ligand 5	Chemokine	3.173	0.014	Up
IL1RN	Interleukin 1 receptor antagonist	IL-1 receptor antagonist	1.341	0.014	Up
Cellular transport/differentiation/proliferation
REG4	Regenerating family member 4	Cellular differentiation and proliferation	1.476	2.97E-06	Up
FABP6	Fatty acid binding protein 6	Fatty acid uptake, transport and metabolism and BA binding	2.207	0.003	Up
SLC2A2	Solute carrier family 2 member 2	Na+/glucose co-transporter	2.998	0.0002	Up
OTOP2	Otopetrin-2	Proton-selective channel	−1.221	0.003	Down
Miscellaneous
CP	Ceruloplasmin	Copper-binding glycoprotein	−1.024	0.014	Down
NUTM2D	NUT family member 2D	Unclear	−1.015	0.017	Down
MYEOV	Myeloma overexpressed	Unclear	1.323	0.008	Up
BEX5	Brain expressed X-linked 5	Unclear	−1.328	0.003	Down

ABAM, abnormal bile acid metabolism; BA, bile acid; BAD, bile acid diarrhoea; IBS-D, irritable bowel syndrome with diarrhoea.