TABLE 3.
Socio-positive behaviors after chronic CBD treatment and acute THC challenge: Duration [s] and frequency (fq) [n] of nosing, anogenital sniffing, climbing on/over, and following the A/J mouse in the social interaction (SI) test following acute THC exposure.
| Genotype |
WT |
Nrg1 TM HET |
||||||
| Chronic treatment |
VEH |
CBD |
VEH |
CBD |
||||
| THC challenge | VEH | THC | VEH | THC | VEH | THC | VEH | THC |
| Nosing [s]^^ | 68.9 ± 8.5 | 90.4 ± 27.4 | 85.8 ± 10.6 | 95.4 ± 13.8 | 59.3 ± 5.15 | 73.4 ± 10.7 | 59.2 ± 5.2 | 107.3 ± 8.9 |
| Anogenital Sniffing [s]* | 20.9 ± 5.9 | 17.5 ± 5.9 | 28 ± 6.7 | 33.7 ± 4.2 | 15.5 ± 2.6 | 21.6 ± 4.7 | 13.6 ± 2.3 | 24.1 ± 3.6 |
| Climbing On/Over [s]^# | 7.9 ± 1.4 | 8.23 ± 3 | 13.3 ± 3.8 | 16.1 ± 5.6 | 7.7 ± 1.5 | 10.8 ± 2.1 | 6.2 ± 1.34 | 20.2 ± 5.4 |
| Following [s] | 3.2 ± 1.5 | 4.61 ± 3.3 | 3.9 ± 1.2 | 7.4 ± 1.9 | 3.1 ± 1.4 | 3.1 ± 1.7 | 1.5 ± 0.6 | 2.2 ± 1.3 |
| Nosing [n] | 77.8 ± 7.5 | 75.3 ± 14.1 | 88.8 ± 10.7 | 84 ± 6.9 | 68.4 ± 5.7 | 76.5 ± 8.6 | 71.5 ± 4.5 | 91 ± 5.3 |
| Anogenital Sniffing [n] +## | 22.8 ± 4.5 | 15.1 ± 3.7 | 27.8 ± 6.3 | 26.2 ± 1.3 | 15.6 ± 2.3 | 21.8 ± 3.7 | 15.3 ± 1.9* | 22.1 ± 1.3 |
| Climbing On/Over [n] + | 9 ± 1.9 | 7.85 ± 2.3 | 13.6 ± 3.1 | 13.5 ± 3.2 | 7.4 ± 1.2 | 11.5 ± 2 | 7.6 ± 1.2** | 18.3 ± 3.6 |
| Following [n] | 4 ± 1.7 | 5.1 ± 3.7 | 6 ± 1.7 | 8.4 ± 1.7 | 4.2 ± 1.8 | 3.7 ± 1.5 | 2.1 ± 0.6 | 2.5 ± 1.1 |
Data expressed as mean ± SEM for wild type-like (WT) and neuregulin 1 transmembrane domain heterozygous (Nrg1 TM HET) mice treated with vehicle (VEH) or cannabidiol (CBD) then later vehicle or Δ9-tetrahydrocannabinol (THC). Main effects are indicated with: ‘genotype’ *p < 0.05; ‘CBD’ #p < 0.05, ##p < 0.01; and ‘THC’ ^p < 0.05, ^^p < 0.01. Interactions between ‘THC’ and ‘genotype’ were found for anogenital sniffing [+p = 0.02] and climbing on/over [+p = 0.02] frequency. Split by effects of ‘genotype’ within these interactions are indicated with * p < 0.05 and ** p < 0.01.