Table 2.
Association Between Frailty Status and Immune Senescence Markers
| Characteristic | Marker of Immune Senescence | ||||
|---|---|---|---|---|---|
| Memory CD4 T Cells | Memory CD8 T Cells | CD28null T Cells | CD4/CD8 Ratio | CD57+CD8+ T Cells | |
| Age | +0.01 | +0.38a | +0.14 | +0.04 | +0.25a |
| ADLs | +0.18 | +0.17 | +0.21 | −0.05 | +0.10 |
| IADLs | +0.16 | +0.26b | +0.16 | −0.08 | +0.08 |
| MMSE | −0.11 | −0.10 | +0.00 | +0.02 | +0.16 |
| GDS score | +0.07 | −0.01 | −0.08 | −0.01 | −0.07 |
| Walking pace | +0.04 | +0.27b | +0.08 | +0.06 | +0.01 |
| Hand grip strength | −0.08 | −0.21 | −0.15 | −0.01 | +0.01 |
| Clinical frailty score | +0.15 | +0.24b | +0.09 | +0.09 | −0.05 |
Values represent Spearman correlations.
Abbreviations: ADLs, activities of daily living; GDS, Geriatric Depression Scale; IADLs, instrumental activities of daily living; MMSE, Mini-Mental State Examination.
a
P < .001.
b
P < .05.