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. 2022 Oct 31;12(4):e45. doi: 10.5415/apallergy.2022.12.e45

Fig. 2. Kinetics of immune tolerance induction.

Fig. 2

AIT dominates the skewing of the T-cell population from allergen-specific Th2 to Treg cells and increases the Bregs population. Both of these cells produce immunosuppressive cytokine IL-10 and suppress allergen-sIgE secretion. In parallel, these cells also induce IgG4 production that displays anti-inflammatory properties. Overall, AIT is considered a successful treatment for allergic inflammation. AIT, allergen immunotherapy; Treg, regulatory T cell; Breg, regulatory B cell; IL, interleukin; sIgE, specific IgE; IgG4, immunoglobulin G4.