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. 2022 Nov 3;10:995732. doi: 10.3389/fcell.2022.995732

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Copyright © 2022 Xu, Zhou, Zhan, Bi and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG pathway enrichment based on Mfuzz clustering. (A) Heatmap of KEGG pathway enrichment. The heatmap scale is based on Z scores ranging from −2 (blue) to 2 (red) with a midpoint of 0 (white); p-value < 0.05. (B,C) KEGG pathway-based enrichment analysis is divided into two subgraphs: cluster 1 and cluster 4 (B), and cluster 3 (C). Cluster 1, cluster 4, and cluster 3 are represented in red, blue, and green, respectively. (D–F) Characteristic KEGG pathways with cluster 3 and 4 proteins were obtained. Cluster 4 proteins are labeled in red on the oxidative phosphorylation (OXPHOS) map (D). Cluster 3 proteins are marked in green on both the linoleic acid map (E) and the arachidonic acid map (F).