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. 2022 Nov 3;10:995732. doi: 10.3389/fcell.2022.995732

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Copyright © 2022 Xu, Zhou, Zhan, Bi and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein domain enrichment analyses and protein-protein interaction (PPI) analysis of DEPs. (A) Protein domain enrichment analyses based on Mfuzz clustering. The heatmap scale is based on Z scores ranging from −2 (blue) to 2 (red) with a midpoint of 0 (white); p-value < 0.05. (B) PPI maps of the DEPs in the control, model, and ZBPYR groups. (C,D) PPI network and modules of cluster 1, 3, and 4 proteins. PPI (C) and modules (D) are proteins associated with the administration of T2DM under chronic psychological stress and ZBPYR treatment. The blue nodes belong to cluster 1, the red nodes belong to cluster 3, the green nodes be a part of cluster 4, and the purple nodes are the other DEPs. The sizes of the nodes reflect the node degree.