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. 2022 Nov 3;10:995732. doi: 10.3389/fcell.2022.995732

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Copyright © 2022 Xu, Zhou, Zhan, Bi and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential mechanism of T2DM with chronic psychological stress and ZBPYR treatment. Compared with control rats, the proteomics of liver MAM in model rats changed, including insulin signaling pathway, oxidative phosphorylation, TCA cycle, amino acid metabolism, lysosome, linoleic acid metabolism, and arachidonic acid metabolism-related proteins, while ZBPYR treatment caused proteomic changes in liver MAM in ZBPYR rats by regulating the expression of the above proteins. This may underlie the molecular basis of T2DM with chronic psychological stress and the potential therapeutic mechanism of ZBPYR.